Description

tert-Butyl 4-Chloro-2-Methyl-5,6-Dihydropyrido[3,4-D]Pyrimidine-7(8H)-Carboxylate CAS NO 1628042-58-9 is a high-purity, advanced pharmaceutical intermediate belonging to the dihydropyridopyrimidine class. This compound is a critical building block in modern medicinal chemistry, valued for its role in constructing complex molecular scaffolds with targeted biological activity. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in oncology and kinase inhibitor research.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs), especially kinase inhibitors.
• Oncology Drug Discovery: Used as a core scaffold for constructing candidate molecules targeting specific cancer pathways.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Synthesis: Employed in multi-step organic syntheses to introduce the dihydropyrido[3,4-d]pyrimidine moiety into more complex molecular architectures.
• Process Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales for new drug candidates.

Basic Information

Product Name	tert-Butyl 4-Chloro-2-Methyl-5,6-Dihydropyrido[3,4-D]Pyrimidine-7(8H)-Carboxylate
CAS No.	1628042-58-9
Molecular Formula	C₁₃H₁₈ClN₃O₂
Molecular Weight	283.75 g/mol
Synonyms	tert-Butyl 4-chloro-2-methyl-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylate; 7-(tert-Butoxycarbonyl)-4-chloro-2-methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; 4-Chloro-2-methyl-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-carboxylic acid tert-butyl ester; 1628042-58-9; tert-Butyl 4-chloro-2-methyl-5,6-dihydro-8H-pyrido[3,4-d]pyrimidine-7-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Chloro-2-Methyl-5,6-Dihydropyrido[3,4-D]Pyrimidine-7(8H)-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.