Description

5-Chloro-n-(2-Isopropoxy-5-Methyl-4-(Piperidin-4-Yl)Phenyl)-4-Nitropyrimidin-2-Amine is a high-purity, advanced pharmaceutical intermediate of significant interest in modern drug discovery. This compound, with CAS number 1622997-11-8, is valued for its complex heterocyclic structure, which serves as a critical building block for synthesizing novel therapeutic agents. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of targeted small-molecule drugs, particularly in oncology and other disease areas requiring sophisticated chemical scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) for targeted therapies.
• Kinase Inhibitor Research: Serves as a core scaffold in the design and development of potent and selective kinase inhibitors.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to optimize drug candidate potency, selectivity, and pharmacokinetic properties.
• Oncology Drug Development: Employed in the research pipeline for creating innovative anti-cancer compounds.
• Chemical Biology Probes: Utilized as a tool compound to study specific biological pathways and protein functions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke chemical synthesis for clients.

Basic Information

Product Name	5-Chloro-n-(2-Isopropoxy-5-Methyl-4-(Piperidin-4-Yl)Phenyl)-4-Nitropyrimidin-2-Amine
CAS No.	1622997-11-8
Molecular Formula	C19H24ClN5O3
Molecular Weight	405.88 g/mol
Synonyms	5-Chloro-N-[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]-4-nitropyrimidin-2-amine; 5-Chloro-N-(2-isopropoxy-5-methyl-4-piperidin-4-ylphenyl)-4-nitropyrimidin-2-amine; 1622997-11-8; UNII-7D2J4J2Q8F; 7D2J4J2Q8F; CHEMBL3186660; BDBM50166657; AKOS009158932; ZINC000004249756
EINECS	Contact for details

Quality Control

Our 5-Chloro-n-(2-Isopropoxy-5-Methyl-4-(Piperidin-4-Yl)Phenyl)-4-Nitropyrimidin-2-Amine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization using techniques such as HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). This compound may be light-sensitive and/or hygroscopic; handling under an inert atmosphere is recommended for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.