Description

(S)-2-((2,6-Dichloropyrimidin-4-Yl)Amino)Propan-1-Ol is a chiral, high-purity chemical building block featuring a pyrimidine core. This compound is of significant value in advanced organic synthesis, particularly for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and synthesis of novel therapeutic agents, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of targeted drug candidates, especially in oncology and antiviral research.
• Kinase Inhibitor Development: Serves as a core structural component for creating potent and selective kinase inhibitors due to its dichloropyrimidine moiety.
• Agrochemical Research: Used in the discovery and synthesis of new generation herbicides and fungicides that require specific stereochemistry for efficacy.
• Chemical Biology Probes: Employed in the design and construction of molecular probes for studying enzyme function and cellular signaling pathways.
• Asymmetric Catalysis Ligand Precursor: Can be utilized to develop novel chiral ligands for asymmetric synthesis applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high stereochemical purity.

Basic Information

Product Name	(S)-2-((2,6-Dichloropyrimidin-4-Yl)Amino)Propan-1-Ol
CAS No.	1620579-30-7
Molecular Formula	C7H9Cl2N3O
Molecular Weight	222.07 g/mol
Synonyms	(S)-1-(2,6-Dichloropyrimidin-4-ylamino)propan-2-ol; (S)-2-((2,6-Dichloro-4-pyrimidinyl)amino)-1-propanol; (S)-2-Amino-1-(2,6-dichloro-4-pyrimidinyl)propanol; 2,6-Dichloro-N-[(1S)-2-hydroxy-1-methylethyl]-4-pyrimidinamine; (S)-2-((2,6-Dichloro-4-pyrimidinyl)amino)propanol; (S)-2-(2,6-Dichloropyrimidin-4-ylamino)propan-1-ol; (S)-DCPAP; 1620579-30-7
EINECS	Contact for details

Quality Control

Our (S)-2-((2,6-Dichloropyrimidin-4-Yl)Amino)Propan-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure high enantiomeric excess (ee) and identity confirmation via NMR and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.