Description

5-(2-Bromo-4-Fluorophenoxy)Pyrimidine-2,4-Diamine is a high-purity, advanced pharmaceutical intermediate characterized by its bromo- and fluoro-substituted phenoxy-pyrimidine structure. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for creating targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in oncology and antiviral research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Process Development: Serves as a key starting material (KSM) or intermediate in the scale-up and optimization of API manufacturing processes.
• Kinase Inhibitor Synthesis: Employed in the construction of pyrimidine-based scaffolds for potential kinase inhibitor therapeutics.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services.
• Academic Research: Used in university and institutional labs for exploratory synthetic chemistry and pharmacological studies.

Basic Information

Product Name	5-(2-Bromo-4-Fluorophenoxy)Pyrimidine-2,4-Diamine
CAS No.	1620482-41-8
Molecular Formula	C10H8BrFN4O
Molecular Weight	299.10 g/mol
Synonyms	2,4-Diamino-5-(2-bromo-4-fluorophenoxy)pyrimidine; 5-(2-Bromo-4-fluorophenoxy)-2,4-pyrimidinediamine; 2-Bromo-4-fluorophenyl 2,4-diaminopyrimidin-5-yl ether; 5-(2-Bromo-4-fluorophenoxy)pyrimidine-2,4-diyldiamine; CAS 1620482-41-8
EINECS	Contact for details

Quality Control

Our 5-(2-Bromo-4-Fluorophenoxy)Pyrimidine-2,4-Diamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.