Description

H2N-PEG11-CH2CH2COOH is a heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine and a carboxylic acid group, separated by a long, flexible PEG spacer. This unique structure makes it an essential linker for bioconjugation, enabling the covalent attachment of biomolecules, drugs, or surfaces while providing enhanced solubility and reduced immunogenicity. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics industries for developing advanced therapeutics, targeted drug delivery systems, and diagnostic assays.

Application

• Bioconjugation and Crosslinking: A versatile linker for coupling peptides, proteins, antibodies, or oligonucleotides to other molecules, nanoparticles, or solid supports.
• PEGylation Reagent: Used to modify therapeutic proteins and peptides to improve their pharmacokinetic profile, stability, and solubility.
• Drug Delivery Systems: A key component in constructing antibody-drug conjugates (ADCs), polymer-drug conjugates, and liposomal formulations for targeted therapy.
• Surface Functionalization: For modifying biosensor surfaces, microarray slides, or chromatography media to create bio-active interfaces.
• Hydrogel Formation: Serves as a building block for creating biocompatible and tunable hydrogels for tissue engineering and controlled release applications.
• Diagnostic Reagent Synthesis: Used in the development of fluorescent probes, enzyme labels, and other diagnostic reagents.

Basic Information

Product Name	H2N-PEG11-CH2CH2COOH
CAS No.	1616426-12-0
Molecular Formula	C31H63NO15
Molecular Weight	689.8 g/mol
Synonyms	11-Aza-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontan-35-oic acid; Amino-PEG11-acid; α-Amino-ω-carboxy undecaethylene glycol; Amine-PEG11-COOH; NH2-PEG11-COOH; Heterobifunctional PEG 11; 11-Amino-3,6,9,12,15,18,21,24,27,30-decaoxadotriacontanoic acid
EINECS	Contact for details

Quality Control

Our H2N-PEG11-CH2CH2COOH is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and functional group integrity. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Molecular Weight Confirmation (MS)	Conforms
Water Content (KF)	≤ 1.0%
Functional Group Analysis	Amino Value: ≥ 90% of theory Acid Value: ≥ 90% of theory

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.