Description

4-(6-Amino-1,3-Dimethyl-1H-Pyrazolo[3,4-D]Pyrimidin-4-Yl)-3-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery. This compound serves as a critical building block for the synthesis of targeted kinase inhibitors, which are essential in developing treatments for various cancers and inflammatory diseases. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of small molecule kinase inhibitors targeting specific oncogenic pathways.
• Anticancer Drug Research: Used in the research and development of novel chemotherapeutic agents, particularly those focused on signal transduction inhibition.
• Biochemical Tool Compound: Serves as a reference standard or a starting material for creating biochemical probes to study enzyme function and cellular mechanisms.
• API Synthesis: Employed in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) for preclinical and clinical studies.
• Medicinal Chemistry Optimization: Utilized for structure-activity relationship (SAR) studies to optimize the potency and selectivity of drug candidates.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	4-(6-Amino-1,3-Dimethyl-1H-Pyrazolo[3,4-D]Pyrimidin-4-Yl)-3-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1616415-40-7
Molecular Formula	C18H27N7O2
Molecular Weight	373.46 g/mol
Synonyms	tert-Butyl 4-(6-amino-1,3-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate; 1,1-Dimethylethyl 4-(6-amino-1,3-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-3-methyl-1-piperazinecarboxylate; 3-Methyl-1-piperazinecarboxylic acid, 4-(6-amino-1,3-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-, 1,1-dimethylethyl ester; BOC-protected pyrazolopyrimidine piperazine intermediate; Kinase inhibitor intermediate 1616415-40-7
EINECS	Contact for details

Quality Control

Our 4-(6-Amino-1,3-Dimethyl-1H-Pyrazolo[3,4-D]Pyrimidin-4-Yl)-3-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We support development under cGMP guidelines for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is sensitive to strong acids and organic solvents; ensure storage areas are well-ventilated and segregated from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.