Description

4-Pyrimidinecarboxamide, 6-[(1-Acetyl-4-Piperidinyl)Amino]-n-[(2R)-3-(3,4-Dihydro-2(1H)-Isoquinolinyl)-2-Hydroxypropyl]- CAS NO 1616397-25-1 is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant value in medicinal chemistry for the research and development of novel therapeutic agents, particularly those targeting central nervous system and oncological pathways. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of proprietary drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates for preclinical and clinical research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new active pharmaceutical ingredients (APIs).
• CNS Drug Development: Serves as a core scaffold for research into compounds targeting neurological and psychiatric disorders.
• Oncology Research: Employed in the development of kinase inhibitors and other targeted cancer therapies.
• Contract Synthesis: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.
• Academic Research: Used in university and institutional labs for chemical biology and drug discovery projects.

Basic Information

Item	Detail
Product Name	4-Pyrimidinecarboxamide, 6-[(1-Acetyl-4-Piperidinyl)Amino]-n-[(2R)-3-(3,4-Dihydro-2(1H)-Isoquinolinyl)-2-Hydroxypropyl]-
CAS No.	1616397-25-1
Molecular Formula	C24H30N6O3
Molecular Weight	450.54 g/mol
Synonyms	6-[(1-Acetyl-4-piperidinyl)amino]-N-[(2R)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-4-pyrimidinecarboxamide; (R)-6-((1-Acetylpiperidin-4-yl)amino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)pyrimidine-4-carboxamide; UNII-9J8T9Q6H6I; 9J8T9Q6H6I; 1616397-25-1; 4-Pyrimidinecarboxamide, 6-[(1-acetyl-4-piperidinyl)amino]-N-[(2R)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-; A proprietary research compound.
EINECS	Contact for details

Quality Control

Our 4-Pyrimidinecarboxamide intermediate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to support regulatory filings. We adhere to cGMP principles where applicable to ensure traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spec)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.