Description

6-Chloro-5-((Trimethylsilyl)ethynyl)pyrimidin-4-amine is a high-purity, advanced pharmaceutical intermediate featuring a unique pyrimidine core functionalized with both chloro and trimethylsilyl-protected ethynyl groups. This compound is of significant value for its role as a versatile building block in modern medicinal chemistry, enabling the synthesis of complex molecules through cross-coupling and click chemistry reactions. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for oncology and antiviral therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small-molecule drugs, especially kinase inhibitors and other enzyme-targeted therapies.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging its heterocyclic structure for biological activity.
• Material Science: Serves as a monomer or functional additive in the creation of specialty polymers and advanced organic electronic materials.
• Chemical Biology & Proteomics: Employed as a tagging or labeling reagent due to its alkyne functionality for bio-conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Academic & Contract Research: Utilized in academic laboratories and CROs (Contract Research Organizations) for method development and exploratory synthesis projects.

Basic Information

Product Name	6-Chloro-5-((Trimethylsilyl)ethynyl)pyrimidin-4-Amine
CAS No.	1615680-91-5
Molecular Formula	C9H14ClN3Si
Molecular Weight	227.77 g/mol
Synonyms	4-Amino-6-chloro-5-[(trimethylsilyl)ethynyl]pyrimidine; 6-Chloro-5-(2-trimethylsilylethynyl)pyrimidin-4-ylamine; 6-Chloro-5-((trimethylsilyl)ethynyl)-4-pyrimidinamine; 5-((Trimethylsilyl)ethynyl)-6-chloropyrimidin-4-amine; 1615680-91-5; TMS-protected ethynyl pyrimidine amine
EINECS	Contact for details

Quality Control

Our 6-Chloro-5-((Trimethylsilyl)ethynyl)pyrimidin-4-amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) documenting all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.