Description

4-Pyrimidinamine, 2-[(3S,4R)-3-Fluoro-4-Methoxy-1-Piperidinyl]- is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of targeted therapeutic agents. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) engaged in the development of novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up synthetic routes for potential therapeutics.
• Targeted Drug Discovery: Particularly relevant for programs focusing on kinase inhibitors or other targets where the pyrimidinamine scaffold is prevalent.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control.
• Custom Synthesis: Basis for further chemical modifications and derivatization to create novel chemical libraries for screening.

Basic Information

Product Name	4-Pyrimidinamine, 2-[(3S,4R)-3-Fluoro-4-Methoxy-1-Piperidinyl]-
CAS No.	1612174-06-7
Molecular Formula	C10H15FN4O
Molecular Weight	226.25 g/mol
Synonyms	2-[(3S,4R)-3-Fluoro-4-Methoxypiperidin-1-yl]pyrimidin-4-amine; (3S,4R)-3-Fluoro-4-methoxy-1-(4-aminopyrimidin-2-yl)piperidine; 2-((3S,4R)-3-Fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-amine; CAS 1612174-06-7; 4-Amino-2-[(3S,4R)-3-fluoro-4-methoxy-1-piperidinyl]pyrimidine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity suitable for research and development applications. All materials are characterized by modern analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and chiral purity is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.