Description

4-Pyrimidinamine, 2-[(3R,4S)-3-Fluoro-4-Methoxy-1-Piperidinyl]- is a high-purity, advanced pharmaceutical intermediate featuring a chiral piperidine-pyrimidine core structure. This compound is critical for the research and development of novel therapeutic agents, particularly in the fields of oncology and central nervous system (CNS) disorders. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex, biologically active molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of targeted small-molecule drugs, especially kinase inhibitors.
• Oncology Research: Used in the development of preclinical and clinical candidates for cancer treatment.
• CNS Drug Discovery: Serves as a core scaffold for compounds targeting neurological pathways.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for commercial API manufacturing.
• Academic & Institutional Research: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies.
• Custom Synthesis: Basis for producing bespoke compounds and derivatives for client-specific projects.

Basic Information

Product Name	4-Pyrimidinamine, 2-[(3R,4S)-3-Fluoro-4-Methoxy-1-Piperidinyl]-
CAS No.	1612174-03-4
Molecular Formula	C10H15FN4O
Molecular Weight	226.25 g/mol
Synonyms	2-[(3R,4S)-3-Fluoro-4-Methoxypiperidin-1-yl]pyrimidin-4-amine; (3R,4S)-3-Fluoro-4-methoxy-1-(4-aminopyrimidin-2-yl)piperidine; 2-((3R,4S)-3-Fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-amine; 4-Amino-2-[(3R,4S)-3-fluoro-4-methoxy-1-piperidinyl]pyrimidine; 1612174-03-4; UNII-Contact for details
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically exceeding 97% (HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Our quality protocols are designed to support GMP-grade applications and rigorous regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Chiral Purity (Chiral HPLC)	≥ 99.0% ee

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.