Description

Mambalgin 1 CAS NO 1609937-15-6 is a high-purity, synthetic peptide compound of significant interest in advanced biochemical and pharmacological research. Its primary value lies in its role as a potent and selective inhibitor of acid-sensing ion channels (ASICs), which are key targets for understanding and modulating pain pathways. This makes it an essential research-grade biochemical for neuroscientists, pharmacologists, and drug discovery teams in the pharmaceutical and biotechnology sectors.

Application

• Neuroscience Research: Critical tool for studying the function and modulation of Acid-Sensing Ion Channels (ASICs) in neuronal signaling and pain perception.
• Analgesic Drug Discovery: Serves as a reference compound and lead molecule in the development of novel, non-opioid pain therapeutics.
• Ion Channel Pharmacology: Used in in vitro assays (e.g., electrophysiology, calcium imaging) to characterize ASIC subtype specificity and inhibitor potency.
• Biochemical Mechanism Studies: Employed to investigate the role of ASICs in physiological and pathological conditions such as ischemia, inflammation, and neurodegeneration.
• Academic & Institutional Research: A key reagent for university labs and research institutes focused on sensory biology and channelopathy.
• Preclinical Development: Used in animal model studies to validate ASIC-related targets and evaluate therapeutic efficacy for pain management.

Basic Information

Item	Details
Product Name	Mambalgin 1
CAS No.	1609937-15-6
Molecular Formula	C184H284N52O55S6
Molecular Weight	~4140.8 g/mol
Synonyms	Mambalgin-1; Mambalgin1; ASIC Inhibitor Mambalgin 1; Peptide Mambalgin I; Acid-sensing ion channel inhibitor from mamba venom; 3FTx-Family Peptide; Recombinant Mambalgin 1; Synthetic Mambalgin-1 peptide
EINECS	Contact for details

Quality Control

Our Mambalgin 1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high biological activity. Each lot is subjected to comprehensive analytical testing, including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and amino acid analysis. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and endotoxin levels is provided with every shipment to support your research compliance.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the lyophilized powder at -20°C or below. Upon reconstitution, aliquot the solution to avoid repeated freeze-thaw cycles and store at -80°C. The product is hygroscopic (moisture-sensitive); ensure the vial is equilibrated to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Single-Chain Integrity	≥ 90% (by HPLC)
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Endotoxin Level	< 10 EU/mg
Biological Activity (ASIC1a Inhibition, IC50)	Reported value provided per batch

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.