Description

2,6-Difluoro-4-Methylbenzene-1-Sulfonyl Chloride is a high-purity, multi-functional chemical building block essential for advanced organic synthesis. Its value lies in its role as a key sulfonylation reagent, enabling the introduction of the sulfonyl group into complex molecular architectures with high selectivity. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and pesticides that require the difluoromethylphenylsulfonyl moiety for enhanced bioactivity and stability.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers, such as sulfonated polymers for ion-exchange membranes or high-performance materials.
• Chemical Research & Development: Employed in academic and industrial labs for method development and exploring new reactions in organofluorine and sulfonyl chemistry.
• Dye and Pigment Industry: Acts as an intermediate for synthesizing specialized dyes and pigments where the sulfonyl chloride group facilitates attachment to chromophores.
• Ligand and Catalyst Design: Useful for constructing sophisticated ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.

Basic Information

Product Name	2,6-Difluoro-4-Methylbenzene-1-Sulfonyl Chloride
CAS No.	1602025-95-5
Molecular Formula	C7H5ClF2O2S
Molecular Weight	226.63 g/mol
Synonyms	2,6-Difluoro-4-methylbenzenesulfonyl chloride; 4-Methyl-2,6-difluorobenzenesulfonyl chloride; 1-(Chlorosulfonyl)-2,6-difluoro-4-methylbenzene; 2,6-Difluoro-p-toluenesulfonyl chloride; 2,6-Difluoro-4-methylphenylsulfonyl chloride; 2,6-Difluoro-4-toluenesulfonyl chloride; DFMBS-Cl
EINECS	Contact for details

Quality Control

Our 2,6-Difluoro-4-Methylbenzene-1-Sulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.