Description

Huwentoxin Xvi is a selective peptide neurotoxin derived from the venom of the Chinese bird spider, *Haplopelma huwenum*. This compound matters as a highly specific research-grade biochemical tool for studying voltage-gated sodium (NaV) channels, particularly in neuroscience and pharmacology. It is needed by academic, pharmaceutical, and biotechnology researchers for ion channel characterization, drug discovery, and the development of novel therapeutic agents targeting neurological pathways.

Application

• Neuroscience Research: As a selective probe for studying the function and distribution of specific NaV channel subtypes in neuronal circuits.
• Drug Discovery & Pharmacology: High-throughput screening and validation of new analgesic or neuroprotective compounds that modulate sodium channel activity.
• Ion Channel Characterization: Electrophysiology studies (e.g., patch-clamp) to investigate channel kinetics, gating properties, and structure-activity relationships.
• Biochemical Assay Development: Used in binding assays and as a standard for developing diagnostic or research kits focused on sodium channel disorders.
• Toxicology & Venom Research: Comparative studies of spider venom components and their mechanisms of action.
• Therapeutic Agent Development: Serves as a lead compound or template for engineering peptides with potential therapeutic applications for pain, epilepsy, or cardiac arrhythmias.

Basic Information

Product Name	Huwentoxin Xvi
CAS No.	1600543-88-1
Molecular Formula	C184H284N52O52S8 (Tentative, based on peptide class)
Molecular Weight	~ 4100 g/mol (Contact for details)
Synonyms	Huwentoxin-XVI; HwTx-XVI; μ-TRTX-Hh1a; NaV1.7 inhibitor peptide; Spider toxin peptide; Voltage-gated sodium channel inhibitor from *Haplopelma huwenum*; Neurotoxic peptide
EINECS	Contact for details

Quality Control

Our Huwentoxin Xvi is produced and tested under stringent conditions to ensure the highest purity and biological activity for research applications. Each batch is characterized using advanced analytical techniques, including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and bioactivity is provided with every shipment to guarantee consistency and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to prevent repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed under anhydrous conditions after each use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Biological Activity (IC50)	Specified per batch (NaV1.7)
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.