Description

4-Difluoromethyl-Pyrimidine-5-Carboxylic Acid Ethyl Ester is a high-value fluorinated pyrimidine derivative, a crucial building block in modern synthetic chemistry. Its core value lies in the difluoromethyl group, which is a key bioisostere used to modulate the physicochemical and metabolic properties of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and anti-inflammatory drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group enhances biological activity and stability.
• Chemical Biology Probe Development: Serves as a versatile scaffold for creating molecular probes to study enzyme function and biological pathways.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced materials with unique electronic or surface properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	4-Difluoromethyl-Pyrimidine-5-Carboxylic Acid Ethyl Ester
CAS No.	1600338-90-6
Molecular Formula	C9H10F2N2O2
Molecular Weight	216.19 g/mol
Synonyms	Ethyl 4-(difluoromethyl)pyrimidine-5-carboxylate; 5-Pyrimidinecarboxylic acid, 4-(difluoromethyl)-, ethyl ester; 4-(Difluoromethyl)pyrimidine-5-carboxylic acid ethyl ester; Ethyl 4-difluoromethylpyrimidine-5-carboxylate; 1600338-90-6; 4-Difluoromethyl-5-ethoxycarbonylpyrimidine
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our fluorinated building blocks. Production follows current Good Manufacturing Practice (cGMP) principles where applicable, ensuring batch-to-batch consistency and reliability. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, verified by advanced analytical techniques including HPLC, GC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.