Description

2-(Difluoromethoxy)Ethan-1-Amine is a specialized organofluorine building block featuring a difluoromethoxy ether linkage attached to an ethylamine backbone. This unique molecular architecture makes it a valuable intermediate for introducing fluorine-containing motifs, which are critical for modulating the physicochemical and metabolic properties of target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance bioactivity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, coatings, and liquid crystals with tailored surface properties.
• Fluorine Chemistry Research: An essential reagent for academic and industrial research exploring new fluorination methodologies and the structure-activity relationships of fluorine-containing compounds.
• Peptide Mimetics & Bio-conjugation: The amine functionality allows for its incorporation into peptide analogs or as a linker for bio-conjugation strategies, improving proteolytic stability.

Basic Information

Product Name	2-(Difluoromethoxy)Ethan-1-Amine
CAS No.	1599344-15-6
Molecular Formula	C₃H₇F₂NO
Molecular Weight	111.09 g/mol
Synonyms	2-(Difluoromethoxy)ethanamine; 2-(Difluoromethoxy)ethylamine; 1-Amino-2-(difluoromethoxy)ethane; Ethanamine, 2-(difluoromethoxy)-; Difluoromethoxyethylamine; O-(2-Aminoethyl) difluoromethyl ether; 1599344-15-6; DFMEA
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)Ethan-1-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (NMR, IR), to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and incompatible with strong acids and strong bases. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (by GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (by GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.