Description

2-(2-Pyrimidinyl)-5,6,7,8-Tetrahydropyrido[4,3-D]Pyrimidine is a high-purity heterocyclic organic compound with a fused pyrimidine-pyridine core structure. This advanced pharmaceutical intermediate is critical for research and development in medicinal chemistry, particularly for its role as a key building block in kinase inhibitor synthesis. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology firms, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the development of novel therapeutic agents targeting various disease pathways.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of small molecule kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its privileged scaffold.
• Biochemical Tool Compound: Serves as a core structure for developing selective probes to study specific enzyme functions and signaling pathways.
• Preclinical Drug Development: Employed in the synthesis of candidate drug molecules for pharmacokinetic and pharmacodynamic evaluation.
• Contract Manufacturing: Supplied to CDMOs for scale-up synthesis under cGMP conditions for clinical trial material production.
• Academic Research: Used in university and institutional labs for fundamental research in organic synthesis and chemical biology.

Basic Information

Item	Detail
Product Name	2-(2-Pyrimidinyl)-5,6,7,8-Tetrahydropyrido[4,3-D]Pyrimidine
CAS No.	1597008-13-3
Molecular Formula	C11H11N5
Molecular Weight	213.24 g/mol
Synonyms	5,6,7,8-Tetrahydro-2-(2-pyrimidinyl)pyrido[4,3-d]pyrimidine; Pyrido[4,3-d]pyrimidine, 5,6,7,8-tetrahydro-2-(2-pyrimidinyl)-; 2-Pyrimidinyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine; THPP; CAS 1597008-13-3
EINECS	Contact for details

Quality Control

Every batch of 2-(2-Pyrimidinyl)-5,6,7,8-Tetrahydropyrido[4,3-D]Pyrimidine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to support your regulatory filings and ensure batch-to-batch consistency for your critical R&D and manufacturing processes. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.