Description

2-Bromo-1-(Pyrimidin-2-yl)ethanone Hydrobromide is a high-purity organic bromide salt, serving as a critical building block in advanced chemical synthesis. This compound is valued for its reactivity as an alkylating agent, enabling the efficient introduction of functionalized pyrimidine moieties into target molecules. It is primarily required by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs) and other complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new pesticides and herbicides that incorporate pyrimidine-based structures for enhanced activity.
• Chemical Biology: Employed as a molecular probe or linker in proteolysis-targeting chimeras (PROTACs) and other bifunctional molecules.
• Material Science: Precursor for synthesizing functionalized organic materials and ligands for metal-organic frameworks (MOFs).
• Academic & Contract Research: Essential reagent for methodological development in organic chemistry and medicinal chemistry laboratories worldwide.

Basic Information

Product Name	2-Bromo-1-(Pyrimidin-2-yl)ethanone Hydrobromide
CAS No.	1588441-02-4
Molecular Formula	C6H6Br2N2O
Molecular Weight	289.93 g/mol
Synonyms	2-Bromo-1-(2-pyrimidinyl)ethanone hydrobromide; 2-Bromo-1-(pyrimidin-2-yl)ethan-1-one hydrobromide; α-Bromo-2-pyrimidyl methyl ketone hydrobromide; 2-Pyrimidinyl bromomethyl ketone hydrobromide; 1-(Pyrimidin-2-yl)-2-bromoethanone HBr; Bromo(pyrimidin-2-yl)methyl ketone hydrobromide; CAS 1588441-02-4
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-(Pyrimidin-2-yl)ethanone Hydrobromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and elemental analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.