Description

(9H-Fluoren-9-Yl)Methoxy]Carbonyl Cys(Msbh)-Oh is a specialized, protected cysteine derivative designed for advanced peptide synthesis and bioconjugation chemistry. This compound is critical for researchers and manufacturers requiring precise control over side-chain reactivity and orthogonal deprotection strategies. It is primarily utilized in the pharmaceutical, biotechnology, and life sciences sectors for the development of novel peptide-based therapeutics, diagnostic probes, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key building block for incorporating cysteine residues with orthogonal protecting groups (Fmoc and Msbh) into peptide chains.
• Bioconjugation and Linker Chemistry: Enables site-specific modification of peptides, proteins, and antibodies for creating antibody-drug conjugates (ADCs) and other biopharmaceuticals.
• Chemical Biology Research: Used in the synthesis of peptide probes and inhibitors to study protein-protein interactions and enzyme function.
• Pharmaceutical Intermediate: Acts as a critical raw material in the multi-step synthesis of complex peptide active pharmaceutical ingredients (APIs).
• Material Science: Potential applications in creating functionalized surfaces and smart biomaterials via thiol-ene or disulfide coupling reactions.

Basic Information

Product Name	(9H-Fluoren-9-Yl)Methoxy]Carbonyl Cys(Msbh)-Oh
CAS No.	1584646-97-8
Molecular Formula	C20H19NO5S
Molecular Weight	385.43 g/mol
Synonyms	Fmoc-Cys(Msbh)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-[(4-methylphenyl)sulfonyl]methyl]-L-cysteine; Fmoc-Cysteine(Msbh)-OH; Fmoc-S-(Msbh)-L-cysteine; Nα-Fmoc-S-(4-methylbenzylsulfonylmethyl)-L-cysteine; L-Cysteine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-S-[[(4-methylphenyl)sulfonyl]methyl]-; Fmoc-Cys(Mts)-OH (common abbreviation); Fmoc-Cys(4-methylbenzylsulfonylmethyl)-OH
EINECS	Contact for details

Quality Control

Our (9H-Fluoren-9-Yl)Methoxy]Carbonyl Cys(Msbh)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.