Description

2-(2,5-Difluorophenyl)-2,2-Difluoroethan-1-Ol is a high-purity fluorinated organic building block of significant interest in advanced chemical synthesis. This compound matters for its role as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its difluorinated phenyl and ethanol motifs are key to modulating biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate unique fluorine-based properties into their molecular targets.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides with enhanced efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor for fluorinated components in advanced display technologies.
• Organic Electronics: Employed in the research and development of materials for OLEDs and other electronic applications.
• Fluorinated Polymer Research: Acts as a monomer or modifier in the synthesis of specialty polymers with unique surface properties and chemical resistance.
• Chemical Biology Probes: Utilized in the creation of fluorinated probes and tags for studying biological mechanisms.

Basic Information

Product Name	2-(2,5-Difluorophenyl)-2,2-Difluoroethan-1-Ol
CAS No.	1581274-15-8
Molecular Formula	C8H6F4O
Molecular Weight	194.13 g/mol
Synonyms	2,2-Difluoro-2-(2,5-difluorophenyl)ethanol; 2-(2,5-Difluorophenyl)-2,2-difluoroethanol; 1-(2,5-Difluorophenyl)-2,2-difluoroethan-1-ol (tautomer); α,α-Difluoro-2,5-difluorobenzeneethanol; 2,5-Difluoro-α,α-difluorobenzeneethanol; DFDFE; (2,5-Difluorophenyl)difluoroethanol
EINECS	Contact for details

Quality Control

Every batch of 2-(2,5-Difluorophenyl)-2,2-Difluoroethan-1-Ol undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. Our quality commitment includes full traceability and compliance with cGMP guidelines where applicable for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.