Description

n-(2E)-Tco-L-Lysine is a specialized, high-purity chemical building block designed for advanced bioconjugation and click chemistry applications. Its core value lies in the trans-cyclooctene (TCO) moiety, which enables rapid, selective, and bioorthogonal reactions with tetrazine derivatives under mild physiological conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics sectors who require precise tools for labeling, drug delivery, and biomaterial development.

Application

• Bioconjugation & Protein Labeling: Site-specific modification of antibodies, peptides, and other biomolecules for imaging and therapeutic applications.
• Pre-Targeted Radioimmunotherapy (PRIT): A key component in multi-step strategies for delivering radioactive isotopes to cancer cells with high specificity.
• In Vivo & In Vitro Imaging Probes: Construction of probes for fluorescence, PET, or SPECT imaging via rapid click chemistry with tetrazine-dyes or radioligands.
• ADC (Antibody-Drug Conjugate) Development: Facilitating the stable and efficient attachment of cytotoxic payloads to targeting antibodies.
• Surface Functionalization: Modification of nanoparticles, polymers, and solid supports for biosensor and diagnostic assay development.
• Chemical Biology Research: A critical tool for studying biological processes through bioorthogonal labeling and tracking in live cells.

Basic Information

Product Name	n-(2E)-Tco-L-Lysine
CAS No.	1580501-94-5
Molecular Formula	C14H24N2O3
Molecular Weight	268.35 g/mol
Synonyms	(2E)-trans-Cyclooct-2-en-1-yloxycarbonyl-L-lysine; TCO-L-Lysine; (2E)-TCO-L-Lys-OH; N6-[(1E,5E)-Cyclooct-2-en-1-yloxycarbonyl]-L-lysine; Nε-TCO-L-Lysine; L-Lysine, N6-[(1E,5E)-2-cycloocten-1-yloxy]carbonyl]-; TCO-PEGn-Lysine precursor; Bioorthogonal click chemistry reagent
EINECS	Contact for details

Quality Control

Our n-(2E)-Tco-L-Lysine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and minimize moisture absorption. Allow the sealed container to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.