Description

(2S,3R)-1-(((9H-Fluoren-9-Yl)Methoxy)Carbonyl)-3-Phenylpyrrolidine-2-Carboxylic Acid is a high-purity, non-natural amino acid derivative featuring a protected amine group via the Fmoc (9-fluorenylmethoxycarbonyl) moiety. This compound is a critical chiral building block for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, enabling precise control over stereochemistry and sequence. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel therapeutic peptides, and for specialized applications in biochemistry and proteomics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, stepwise construction of custom peptides.
• Pharmaceutical R&D: A crucial intermediate in the synthesis of peptide-based drug candidates targeting GPCRs, enzymes, and other biological pathways.
• Peptidomimetic Design: Used to incorporate constrained proline analogs into scaffolds to enhance metabolic stability and bioavailability.
• Bioconjugation: Serves as a specialized linker or component for creating peptide-protein or peptide-small molecule conjugates.
• Chemical Biology Probes: Employed in the synthesis of labeled or tagged peptides for studying protein-protein interactions and cellular processes.
• Academic Research: A valuable reagent for universities and research institutes exploring peptide structure-activity relationships (SAR).

Basic Information

Product Name	(2S,3R)-1-(((9H-Fluoren-9-Yl)Methoxy)Carbonyl)-3-Phenylpyrrolidine-2-Carboxylic Acid
CAS No.	1579983-87-1
Molecular Formula	C26H23NO4
Molecular Weight	413.47 g/mol
Synonyms	Fmoc-(2S,3R)-3-phenylproline; (2S,3R)-Fmoc-3-phenylproline; 1-Fmoc-3-phenyl-D-proline; Fmoc-3-phenyl-D-proline; (2S,3R)-1-(9-Fluorenylmethoxycarbonyl)-3-phenylpyrrolidine-2-carboxylic acid; (2S,3R)-3-Phenyl-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-2-carboxylic acid; Fmoc-D-3-phenylproline
EINECS	Contact for details

Quality Control

Our (2S,3R)-1-(((9H-Fluoren-9-Yl)Methoxy)Carbonyl)-3-Phenylpyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. Certificates of Analysis (COA) detailing purity, chiral integrity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.