Description

2,5-Difluorophenyl Chlorothioformate is a specialized organosulfur reagent featuring a chlorothioformate group attached to a difluorinated aromatic ring. This compound matters as a versatile and reactive building block for introducing the 2,5-difluorophenylthio moiety into more complex molecular architectures, particularly in advanced synthetic chemistry. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing sulfur and fluorine atoms for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the difluorophenyl group imparts specific biological activity.
• Material Science Research: Serves as a monomer or modifying agent in the development of specialty polymers and advanced materials with unique properties.
• Ligand and Catalyst Preparation: Employed in the synthesis of specialized ligands for metal catalysis and organocatalysts.
• Chemical Biology Probes: Useful for creating activity-based probes or affinity labels to study enzyme function and protein interactions.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2,5-Difluorophenyl Chlorothioformate
CAS No.	1579306-63-0
Molecular Formula	C7H3ClF2OS
Molecular Weight	208.61 g/mol
Synonyms	Chlorothioformic Acid O-(2,5-Difluorophenyl) Ester; 2,5-Difluorophenyl Chlorothioate; O-(2,5-Difluorophenyl) Chlorothioformate; 2,5-Difluorophenyl Carbonochloridothioate; Carbonochloridothioic Acid O-(2,5-Difluorophenyl) Ester; 2,5-DFP-CTF
EINECS	Contact for details

Quality Control

Every batch of 2,5-Difluorophenyl Chlorothioformate is produced and tested under a strict quality management system. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for purity, identity, and impurity profiles to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Recommended storage temperature is 2-8°C for long-term stability. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, oxidizing agents, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.