Description

2-Bromo-3,4-Difluorobenzyl Alcohol is a versatile fluorinated benzyl alcohol derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of bromine and fluorine atoms, which enable selective functionalization and modulate the electronic properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in fluorine-containing drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluorobenzyl moiety can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Acts as a precursor in the synthesis of fluorinated aromatic cores for electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct complex biaryl systems.
• Ligand & Catalyst Development: Useful for preparing specialized ligands and organocatalysts used in asymmetric synthesis and material science.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	2-Bromo-3,4-Difluorobenzyl Alcohol
CAS No.	1578156-19-0
Molecular Formula	C7H5BrF2O
Molecular Weight	223.02 g/mol
Synonyms	(2-Bromo-3,4-difluorophenyl)methanol; 3,4-Difluoro-2-bromobenzyl alcohol; 1-(Bromo)-2,3-difluoro-4-(hydroxymethyl)benzene; Benzyl alcohol, 2-bromo-3,4-difluoro-; α-Hydroxy-2-bromo-3,4-difluorotoluene
EINECS	Contact for details

Quality Control

Our 2-Bromo-3,4-Difluorobenzyl Alcohol is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is easily oxidized; for long-term storage, consider maintaining under an inert atmosphere (e.g., nitrogen or argon). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.