Description

3-(2-Methyl-4-Oxo-1,4-Dihydropyrimido[1,2-B]Indazol-3-Yl)Propanoic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused heterocyclic structure. This compound is of significant value in medicinal chemistry for the research and development of novel therapeutic agents, particularly as a key building block for kinase inhibitors. It is primarily sought after by pharmaceutical R&D departments, biotechnology firms, and contract research organizations (CROs) engaged in the synthesis of targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potent and selective kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry Research: Used as a core scaffold or a derivatization point for structure-activity relationship (SAR) studies to optimize drug candidate potency and selectivity.
• Biochemical Probe Development: Employed in the creation of chemical probes to study specific biological pathways and protein functions in academic and industrial laboratories.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the cGMP production of active pharmaceutical ingredients (APIs) in clinical trial batches.
• Library Synthesis for High-Throughput Screening (HTS): Utilized to generate focused chemical libraries based on the privileged pyrimidoindazole core for screening against novel biological targets.

Basic Information

Product Name	3-(2-Methyl-4-Oxo-1,4-Dihydropyrimido[1,2-B]Indazol-3-Yl)Propanoic Acid
CAS No.	1573547-48-4
Molecular Formula	C15H13N3O3
Molecular Weight	283.28 g/mol
Synonyms	3-(2-Methyl-4-oxo-1,4-dihydropyrimido[1,2-b]indazol-3-yl)propanoic acid; 3-(2-Methyl-4-oxo-1H-pyrimido[1,2-b]indazol-3(4H)-yl)propanoic acid; 1573547-48-4; Propanoic acid, 3-(2-methyl-4-oxo-1,4-dihydropyrimido[1,2-b]indazol-3-yl)-; Pyrimido[1,2-b]indazole-3-propanoic acid derivative
EINECS	Contact for details

Quality Control

Our 3-(2-Methyl-4-Oxo-1,4-Dihydropyrimido[1,2-B]Indazol-3-Yl)Propanoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.