Description

4-Bromo-2-Fluoro-3-Methylaniline is a high-purity halogenated aniline derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific bromo-fluoro substitution patterns into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where the specific halogen pattern confers biological activity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers and liquid crystals.
• Dye and Pigment Manufacturing: Acts as an intermediate for creating halogenated aromatic dyes with enhanced lightfastness and color properties.
• Cross-Coupling Reactions: An excellent substrate for Buchwald-Hartwig amination and Suzuki-Miyaura cross-coupling reactions to form complex biaryl structures.
• Chemical Research & Development: Employed in academic and industrial labs for methodological studies and library synthesis in medicinal chemistry.

Basic Information

Product Name	4-Bromo-2-Fluoro-3-Methylaniline
CAS No.	1540204-53-2
Molecular Formula	C7H7BrFN
Molecular Weight	204.04 g/mol
Synonyms	3-Methyl-4-bromo-2-fluoroaniline; 2-Fluoro-3-methyl-4-bromoaniline; 4-Bromo-2-fluoro-3-methylbenzenamine; Benzenamine, 4-bromo-2-fluoro-3-methyl-; 1540204-53-2; 4-Br-2-F-3-Me-aniline
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Fluoro-3-Methylaniline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed specifications for every shipment, supporting compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or opaque.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Melting Point	Contact for details
Heavy Metals	<10 ppm
Residue on Ignition	<0.1%
Water Content (KF)	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.