Description

2-Chloro-4-Fluoro-5-Methylbenzyl Alcohol is a versatile fluorinated benzyl alcohol derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of chlorine and fluorine substituents on the aromatic ring, which allows for precise tuning of electronic and steric properties in target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a fluorinated building block for the synthesis of liquid crystal compounds used in display technologies.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and charge-transport materials.
• Cross-Coupling Reactions: The benzyl alcohol group can be transformed into various functionalities, making it a valuable substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions.
• Protecting Group Chemistry: Can be used to introduce and later remove the benzyl protecting group in complex multi-step syntheses.
• Fluorine-Containing Dye & Pigment Intermediates: Utilized in the synthesis of specialty dyes and pigments where fluorine substitution alters color fastness and solubility.

Basic Information

Product Name	2-Chloro-4-Fluoro-5-Methylbenzyl Alcohol
CAS No.	1536543-76-6
Molecular Formula	C8H8ClFO
Molecular Weight	174.60 g/mol
Synonyms	(2-Chloro-4-fluoro-5-methylphenyl)methanol; 2-Chloro-4-fluoro-5-methylbenzenemethanol; 1-(Chloro-4-fluoro-5-methylphenyl)methanol; 2-Chloro-4-fluoro-5-methyl-benzyl alcohol; 5-(Hydroxymethyl)-2-chloro-4-fluorotoluene; α-Hydroxy-2-chloro-4-fluoro-5-methyltoluene; 2-Chloro-4-fluoro-5-methylphenylcarbinol
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and commercial synthesis. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy to verify identity, purity, and consistency. Certificates of Analysis (COA) are available upon request for every batch, providing detailed chromatographic and spectroscopic data. Our quality management system is designed to support cGMP and ISO standards for traceability and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.