Description

(2S)-3-Cyclobutoxy-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Propanoic Acid is a sophisticated, optically active amino acid derivative designed for advanced chemical synthesis. This high-purity building block is critical for researchers and manufacturers requiring precise stereochemistry and functional group compatibility in complex molecule assembly. It is primarily utilized in the pharmaceutical and biotechnology sectors for the development of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new peptide drugs and bioactive molecules.
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected amino acid building block, particularly with the Fmoc (9-fluorenylmethoxycarbonyl) protecting group, for the automated synthesis of peptides.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the synthesis of compound libraries for drug discovery programs.
• Bioconjugation: Serves as a linker or spacer molecule in the design of antibody-drug conjugates (ADCs) and other targeted biopharmaceuticals.
• Chemical Biology Probes: Integral for creating labeled or modified peptides used as tools to study biological processes and protein interactions.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized fine chemicals for clients.

Basic Information

Product Name	(2S)-3-Cyclobutoxy-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Propanoic Acid
CAS No.	1509911-79-8
Molecular Formula	C22H23NO5
Molecular Weight	381.42 g/mol
Synonyms	Fmoc-3-cyclobutoxy-L-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-cyclobutoxy-L-alanine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-cyclobutoxypropanoic acid; Fmoc-L-3-cyclobutoxyalanine; Fmoc-Cyc(ButO)-OH; Nα-Fmoc-O-cyclobutyl-L-serine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclobutoxypropanoic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical applications. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere or with desiccant for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 97.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.