Description

3,4-Difluoro-5-Methylaniline is a high-purity fluorinated aniline derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms and a methyl group on the aromatic ring, which significantly influences the electronic and steric properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with enhanced potency, metabolic stability, and selectivity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where the fluorine atoms contribute to improved biological activity, photostability, and systemic uptake in plants.
• Material Science Precursor: Employed in the synthesis of specialty polymers, liquid crystals, and advanced electronic materials that require fluorinated aromatic components for specific thermal, optical, or dielectric properties.
• Organic Synthesis Building Block: Facilitates various coupling reactions (e.g., Buchwald-Hartwig amination, Suzuki coupling) and serves as a starting material for heterocyclic compounds like benzimidazoles and quinazolines.
• Dye and Pigment Intermediate: Acts as a precursor in the manufacture of specialized fluorinated dyes and pigments, offering improved lightfastness and color properties.

Basic Information

Product Name	3,4-Difluoro-5-Methylaniline
CAS No.	1505944-46-6
Molecular Formula	C7H7F2N
Molecular Weight	143.13 g/mol
Synonyms	5-Methyl-3,4-difluoroaniline; 3,4-Difluoro-5-methylbenzenamine; Benzenamine, 3,4-difluoro-5-methyl-; 3,4-Difluoro-5-methyl-phenylamine; 2,3-Difluoro-6-methylaniline; 3,4-Difluoro-5-methyl aniline
EINECS	Contact for details

Quality Control

Our 3,4-Difluoro-5-Methylaniline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0% (Area %)
Water Content (KF)	≤0.5%
Related Substances (HPLC)	Total impurities ≤2.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.