Description

((2R,3R,4R,5R)-3-(Benzoyloxy)-4-Chloro-5-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)-4-Methyltetrahydrofuran-2-Yl)Methyl Benzoate is a high-purity, structurally complex nucleoside analog derivative. This compound is a critical advanced pharmaceutical intermediate (API intermediate) used in the synthesis of novel antiviral and anticancer therapeutics. It is primarily required by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the development of next-generation nucleoside-based drugs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of modified nucleoside analogs with potential antiviral or anticancer activity.
• Antiviral Drug Research: Serves as a precursor in the development of novel therapeutics targeting viral polymerases (e.g., for hepatitis, HIV, or emerging viral threats).
• Oncology Research: Used in medicinal chemistry programs to create prodrugs or active metabolites designed to inhibit cancer cell proliferation.
• Biochemical Tool: Employed in enzymatic studies to investigate substrate specificity and inhibition mechanisms of nucleoside-processing enzymes.
• Process Chemistry & Scale-Up: Utilized in route scouting and optimization for the commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Custom Synthesis & Labeling: Basis for the preparation of isotopically labeled (e.g., deuterated, C13) versions for pharmacokinetic and metabolic studies.

Basic Information

Product Name	((2R,3R,4R,5R)-3-(Benzoyloxy)-4-Chloro-5-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)-4-Methyltetrahydrofuran-2-Yl)Methyl Benzoate
CAS No.	1496551-71-3
Molecular Formula	C25H21ClN2O7
Molecular Weight	496.90 g/mol
Synonyms	4'-Chloro-2'-deoxy-2',3'-di-O-benzoyluridine derivative; 1-((2R,3R,4R,5R)-3-(Benzoyloxy)-4-chloro-5-((benzoyloxy)methyl)-4-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 4-Chloro-2,3-di-O-benzoyl-2-deoxyuridine analog; Benzoylated chlorinated uridine intermediate; Nucleoside analog intermediate CAS 1496551-71-3
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality control protocols suitable for pharmaceutical development. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and chemical purity. Our quality system is designed to support regulatory filings, and comprehensive Certificates of Analysis (COA) with full analytical data are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.