Description

Click Amino Acid / Endo-Bcn – Fmoc – L - Lysine (Bcn) is a specialized, high-purity amino acid derivative designed for advanced bioconjugation and chemical biology applications. This compound matters because it serves as a critical building block for the site-specific modification of peptides, proteins, and other biomolecules using bioorthogonal click chemistry. Researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors need it to develop targeted drug conjugates, create novel biomaterials, and engineer probes for advanced research.

Application

• Peptide & Protein Conjugation: Site-specific labeling and functionalization of biomolecules via strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry.
• Antibody-Drug Conjugate (ADC) Development: Synthesis of linker-payload constructs for creating next-generation targeted cancer therapeutics.
• Chemical Biology Probes: Incorporation into peptides for the development of activity-based probes, imaging agents, and diagnostic tools.
• Biomaterial Engineering: Functionalization of hydrogels, surfaces, and nanoparticles to create bioactive scaffolds for tissue engineering and drug delivery.
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected lysine derivative for the controlled introduction of BCN groups during Fmoc-based peptide synthesis.
• Proteomics Research: Enabling chemoselective tagging and enrichment strategies for studying protein function and interactions.

Basic Information

Product Name	Click Amino Acid / Endo-Bcn – Fmoc – L - Lysine (Bcn)
CAS No.	1493802-95-1
Molecular Formula	C31H39N3O6
Molecular Weight	549.66 g/mol
Synonyms	Fmoc-Lys(Bcn)-OH; N6-[(1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethoxycarbonyl]-N2-(9-fluorenylmethoxycarbonyl)-L-lysine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl)methoxy)carbonyl)amino)hexanoic acid; Fmoc-Lys(Endo-BCN)-OH; BCN-Fmoc-Lysine; Fmoc-L-lysine(Bcn); Fmoc-Lys(Bicyclo[6.1.0]non-4-yn-9-ylmethyl carbamate)-OH
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and structural integrity. Certificates of Analysis (COA) with detailed chromatographic data are available upon request. We adhere to strict quality management protocols suitable for research and development use in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.