Description

2-Ethoxy-3,5-Difluorobenzenesulfonylchloride is a high-purity, specialized organosulfur compound that serves as a critical building block in advanced chemical synthesis. Its value lies in its role as a versatile sulfonylation reagent, enabling the introduction of the 2-ethoxy-3,5-difluorophenylsulfonyl moiety into target molecules with high selectivity. This compound is primarily needed by research and development teams and production chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for sulfonamide-based drugs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides, where the difluorinated ethoxybenzene structure can enhance biological activity and environmental profile.
• Material Science Research: Employed in the creation of specialized monomers or additives for advanced polymers, where the sulfonyl chloride group facilitates polymerization or modification.
• Chemical Biology & Proteomics: Acts as a reactive handle for labeling or modifying biomolecules in probe development and activity-based protein profiling studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring this precise sulfonylation reagent.
• Library Synthesis for Drug Discovery: Utilized in high-throughput and combinatorial chemistry to generate diverse compound libraries for screening against novel biological targets.

Basic Information

Product Name	2-Ethoxy-3,5-Difluorobenzenesulfonylchloride
CAS No.	1487710-75-7
Molecular Formula	C8H7ClF2O3S
Molecular Weight	256.65 g/mol
Synonyms	1-Ethoxy-2,4-difluoro-5-sulfonylchloridebenzene; 3,5-Difluoro-2-ethoxybenzenesulfonyl chloride; 2,4-Difluoro-5-(chlorosulfonyl)phenetole; Benzenesulfonyl chloride, 2-ethoxy-3,5-difluoro-; 5-Ethoxy-2,4-difluorobenzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 2-Ethoxy-3,5-Difluorobenzenesulfonylchloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.