Description

(5-Bromo-2-(Methylthio)Pyrimidin-4-Yl)Methyl Methanesulfonate is a high-value pyrimidine derivative and a key synthetic intermediate in modern organic chemistry. Its core value lies in its dual functionality, featuring both a reactive bromine atom and a methanesulfonate (mesylate) ester group, making it an essential building block for constructing complex molecular architectures. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitor drugs and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the pyrimidine core's bioactivity.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating molecular probes and affinity tags to study protein function and interactions.
• Material Science Research: Employed in the development of advanced organic electronic materials and liquid crystals due to its aromatic heterocyclic structure.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form new carbon-carbon bonds.
• Nucleoside Analogue Development: Acts as a key intermediate in the synthesis of modified nucleosides and nucleotides for antiviral or anticancer research.

Basic Information

Product Name	(5-Bromo-2-(Methylthio)Pyrimidin-4-Yl)Methyl Methanesulfonate
CAS No.	1481616-19-6
Molecular Formula	C8H9BrN2O3S2
Molecular Weight	325.20 g/mol
Synonyms	4-((Methanesulfonyloxy)methyl)-5-bromo-2-(methylthio)pyrimidine; 5-Bromo-2-(methylthio)-4-pyrimidinylmethyl methanesulfonate; (5-Bromo-2-methylsulfanyl-pyrimidin-4-yl)methyl methanesulfonate; Mesylate ester of (5-bromo-2-(methylthio)pyrimidin-4-yl)methanol; 1481616-19-6; 4-Pyrimidinemethanol, 5-bromo-2-(methylthio)-, methanesulfonate (ester)
EINECS	Contact for details

Quality Control

Our (5-Bromo-2-(Methylthio)Pyrimidin-4-Yl)Methyl Methanesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.