Description

Pyrazolo[1,5-A]Pyrimidine, 7-Chloro-2-(3,4-Dimethoxyphenyl)-6-Ethyl-5-Methyl- is a high-purity, advanced pharmaceutical intermediate belonging to the pyrazolopyrimidine class of heterocyclic compounds. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates targeting various disease pathways.
• Kinase Inhibitor Research: Used in the development and optimization of small molecule kinase inhibitors due to the privileged pyrazolopyrimidine core structure.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship (SAR) studies to explore and enhance biological activity and selectivity.
• Process Chemistry & Scale-Up: Acts as a starting material or intermediate in the development of robust, scalable synthetic routes for API manufacturing.
• Chemical Biology Probes: Utilized in the creation of chemical probes for investigating biological mechanisms and target validation.
• Custom Synthesis Projects: Supplied for bespoke organic synthesis projects requiring complex, multi-substituted heterocyclic frameworks.

Basic Information

Item	Details
Product Name	Pyrazolo[1,5-A]Pyrimidine, 7-Chloro-2-(3,4-Dimethoxyphenyl)-6-Ethyl-5-Methyl-
CAS No.	1464091-54-0
Molecular Formula	C₁₇H₁₈ClN₃O₂
Molecular Weight	331.80 g/mol
Synonyms	7-Chloro-2-(3,4-dimethoxyphenyl)-6-ethyl-5-methylpyrazolo[1,5-a]pyrimidine; 6-Ethyl-7-chloro-5-methyl-2-(3,4-dimethoxyphenyl)pyrazolo[1,5-a]pyrimidine; 1464091-54-0; Pyrazolo[1,5-a]pyrimidine, 7-chloro-2-(3,4-dimethoxyphenyl)-6-ethyl-5-methyl-; 2-(3,4-Dimethoxyphenyl)-7-chloro-6-ethyl-5-methylpyrazolo[1,5-a]pyrimidine
EINECS	Contact for details

Quality Control

Our Pyrazolo[1,5-A]Pyrimidine intermediate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting regulatory filings for preclinical and clinical-stage materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.