Description

Z-Phe-Lys(Boc)-Coch2Cl is a specialized, protected dipeptide derivative featuring a chloromethyl ketone functional group. This compound is a critical building block in the synthesis of protease inhibitors and other biologically active peptides, offering precise control over molecular structure and reactivity. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery, development, and advanced proteomics applications.

Application

• Protease Inhibitor Synthesis: Serves as a key electrophilic intermediate for creating irreversible, active-site directed inhibitors of serine and cysteine proteases.
• Pharmaceutical Research: Used in the design and development of therapeutic agents targeting conditions like viral infections, inflammatory diseases, and cancer.
• Biochemical Tool Development: Employed to create activity-based probes (ABPs) for labeling and studying protease activity in complex biological systems.
• Peptide Chemistry: Acts as a versatile building block in solid-phase and solution-phase peptide synthesis (SPPS) for introducing specific functional handles.
• Chemical Biology Studies: Facilitates the investigation of enzyme mechanisms and the identification of novel protease targets.

Basic Information

Product Name	Z-Phe-Lys(Boc)-Coch2Cl
CAS No.	1456879-69-8
Molecular Formula	C30H39ClN4O7
Molecular Weight	603.10 g/mol
Synonyms	Z-Phe-Lys(Boc)-CH2Cl; Benzyloxycarbonyl-Phenylalanyl-Nε-tert-Butyloxycarbonyl-Lysyl Chloromethyl Ketone; N-[(Benzyloxy)carbonyl]-L-phenylalanyl-N6-[(1,1-dimethylethoxy)carbonyl]-L-lysyl chloromethane; Z-Phe-Lys(Boc)-CMK; Chloromethyl Ketone Derivative of Z-Phe-Lys(Boc); Protease Inhibitor Precursor; Peptidyl Chloromethyl Ketone
EINECS	Contact for details

Quality Control

Our Z-Phe-Lys(Boc)-Coch2Cl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, freezer environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.