Description

3-((3As,4R,6S,6Ar)-6-(2-Hydroxyethoxy)-2,2-Dimethyltetrahydro- 4H-Cyclopenta[D][1,3]Dioxol-4-Yl)-5-(Propylthio)-3H-[1,2,3] Triazolo[4,5-D]Pyrimidin-7-Ol is a sophisticated nucleoside analog derivative, a key advanced intermediate in modern pharmaceutical synthesis. This compound is valued for its role in the development of novel antiviral and anticancer therapeutics, particularly as a precursor for modified nucleosides and nucleotides. It is essential for research institutions and pharmaceutical companies engaged in the discovery and process development of next-generation small molecule drugs.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antiviral agents, including potential treatments for viral infections.
• Anticancer Drug Research: Serves as a precursor in the development of nucleoside-based chemotherapeutic compounds targeting DNA/RNA synthesis.
• Biochemical Research: Used in enzymatic studies and as a substrate analog to investigate nucleotide metabolism and related pathways.
• Process Chemistry & Scale-Up: Employed in the optimization and kilogram-scale production of active pharmaceutical ingredients (APIs) for clinical trials.
• Protease Inhibitor Synthesis: May be utilized in the construction of complex molecular scaffolds for protease inhibitor development.
• Labeled Compound Synthesis: A candidate for the introduction of isotopic labels (e.g., deuterium, carbon-13) for pharmacokinetic and metabolic studies.

Basic Information

Product Name	3-((3As,4R,6S,6Ar)-6-(2-Hydroxyethoxy)-2,2-Dimethyltetrahydro- 4H-Cyclopenta[D][1,3]Dioxol-4-Yl)-5-(Propylthio)-3H-[1,2,3] Triazolo[4,5-D]Pyrimidin-7-Ol
CAS No.	1456538-51-4
Molecular Formula	C18H25N5O5S
Molecular Weight	423.49 g/mol
Synonyms	5-(Propylthio)-3-((3aR,4R,6S,6aR)-6-(2-hydroxyethoxy)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol; 3H-[1,2,3]Triazolo[4,5-d]pyrimidin-7-ol, 3-((3aR,4R,6S,6aR)-6-(2-hydroxyethoxy)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)-5-(propylthio)-; Protected Nucleoside Triazole Intermediate; Cyclopentadioxolyl Triazolopyrimidinone Derivative
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical research and development applications. Quality is verified through comprehensive analytical techniques including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, identity, and impurity profiles to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.