Description

6-Azido-L-Norleucine Hcl is a non-proteinogenic amino acid derivative featuring an azido functional group, making it a valuable click chemistry reagent. This compound is essential for researchers and manufacturers requiring a bio-orthogonal handle for site-specific bioconjugation and labeling applications. It is primarily utilized in pharmaceutical R&D, proteomics, and the synthesis of novel peptide-based therapeutics and diagnostics.

Application

• Click Chemistry Reagent: Acts as a metabolic precursor for incorporating azide groups into proteins and other biomolecules for subsequent copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC).
• Pharmaceutical Research: Used in the development and synthesis of novel peptide-drug conjugates (PDCs) and targeted therapeutics.
• Proteomics & Bioimaging: Enables site-specific labeling of proteins for studies involving protein trafficking, interaction, and visualization via fluorescent dyes.
• Chemical Biology Tool: Serves as a building block for expanding the genetic code or creating amino acid analogs with unique chemical properties.
• Material Science: Can be used to functionalize surfaces or polymers with bioactive peptides for biomedical engineering applications.
• Antibody-Drug Conjugate (ADC) Development: Facilitates the creation of stable, homogeneous linker-payload constructs for next-generation ADCs.

Basic Information

Product Name	6-Azido-L-Norleucine Hcl
CAS No.	1454334-76-9
Molecular Formula	C6H12N4O2 • HCl
Molecular Weight	208.64 g/mol (Free base: 172.18 g/mol)
Synonyms	(S)-2-Amino-6-azidohexanoic acid hydrochloride; L-2-Amino-6-azidocaproic acid HCl; 6-Azido-L-homoalanine HCl; Azidonorleucine HCl; N6-Azido-L-norleucine hydrochloride; 6-N3-L-Nle-OH • HCl; AHA (6-Azidohexanoic acid) amino acid derivative
EINECS	Contact for details

Quality Control

Our 6-Azido-L-Norleucine Hcl is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for research and development purposes. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While typically supplied as a research-grade chemical, production can be aligned with cGMP standards for advanced applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Assay (Titration)	≥ 98%
Optical Rotation	[α]²⁰D = Specific value provided on COA
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.