Description

Fmoc-S-Benzyl-Dl-Homocysteine CAS NO 1452573-79-3 is a protected, racemic amino acid derivative widely used as a key building block in solid-phase peptide synthesis (SPPS). Its value lies in providing a versatile intermediate for introducing the non-proteinogenic homocysteine residue with orthogonal protection for the thiol and amine functionalities. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for creating peptide-based drugs, bioconjugates, and investigating structure-activity relationships.

Application

• Solid-Phase Peptide Synthesis (SPPS): A crucial intermediate for the controlled incorporation of homocysteine into peptide chains.
• Pharmaceutical Research & Development: Used in the synthesis of novel therapeutic peptides and peptidomimetics targeting various diseases.
• Bioconjugation Chemistry: Serves as a precursor for creating linkers or functionalized peptides for antibody-drug conjugates (ADCs) or protein labeling.
• Chemical Biology Probes: Enables the study of protein function and interactions through the introduction of modified cysteine/homocysteine analogs.
• Combinatorial Chemistry Libraries: A valuable building block for generating diverse compound libraries for high-throughput screening.
• Academic & Institutional Research: Supports fundamental studies in organic synthesis, peptide chemistry, and medicinal chemistry.

Basic Information

Product Name	Fmoc-S-Benzyl-Dl-Homocysteine
CAS No.	1452573-79-3
Molecular Formula	C26H25NO4S
Molecular Weight	447.55 g/mol
Synonyms	Fmoc-DL-Hcy(SBn)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-benzyl-DL-homocysteine; Fmoc-S-benzyl-DL-homocysteine; Fmoc-Homocysteine(S-Benzyl)-OH, DL-; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(benzylthio)butanoic acid; Fmoc-DL-homocysteine(S-benzyl); N-Fmoc-S-benzyl-DL-homocysteine
EINECS	Contact for details

Quality Control

Our Fmoc-S-Benzyl-Dl-Homocysteine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to confirm the racemic mixture. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.