Description

Ethyl 4-(3-Chloro-4-Fluorophenyl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant synthetic utility. This compound serves as a critical building block in the development of novel active pharmaceutical ingredients (APIs), particularly within the dihydropyrimidinone (DHPM) class, which is known for its diverse biological activities. It is essential for research and development chemists and process scale-up teams in the pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel dihydropyrimidinone-based drug candidates with potential therapeutic applications.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities.
• Process Chemistry & Scale-Up: Serves as a defined intermediate for the reliable and reproducible manufacturing of target APIs under GMP conditions.
• Library Synthesis: A valuable scaffold for generating diverse compound libraries for high-throughput screening in drug discovery programs.
• Chemical Biology Probes: Can be utilized to create specialized molecular probes for studying biological pathways and target validation.

Basic Information

Product Name	Ethyl 4-(3-Chloro-4-Fluorophenyl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
CAS No.	1449008-02-9
Molecular Formula	C15H14ClFN2O3
Molecular Weight	324.73 g/mol
Synonyms	Ethyl 4-(3-chloro-4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; 5-Carbethoxy-4-(3-chloro-4-fluorophenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one; 4-(3-Chloro-4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester; 3,4-Dihydropyrimidin-2(1H)-one derivative; Biginelli Reaction Product; DHPM Derivative
EINECS	Contact for details

Quality Control

Our Ethyl 4-(3-Chloro-4-Fluorophenyl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets exacting standards for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.