Description

1-[2-Amino-4-(Trifluoromethyl)Phenyl]-2,2,2-Trifluoroethan-1-One is a high-value, multi-functional trifluoromethylated aniline derivative, serving as a critical advanced pharmaceutical intermediate (API) and agrochemical building block. Its unique structure, featuring both amino and trifluoroacetyl functional groups on a benzotrifluoride core, makes it indispensable for synthesizing complex molecules with enhanced biological activity and metabolic stability. This compound is primarily sought by R&D and production teams in the pharmaceutical and crop protection industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or functionalization agent for specialty polymers and advanced organic electronic materials.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalytic processes.
• Fluorinated Dye and Pigment Intermediate: Used in the synthesis of specialty colorants with superior lightfastness and chemical resistance.
• Research & Development: A valuable tool for medicinal and synthetic chemists in academia and industry for structure-activity relationship (SAR) studies.

Basic Information

Item	Details
Product Name	1-[2-Amino-4-(Trifluoromethyl)Phenyl]-2,2,2-Trifluoroethan-1-One
CAS No.	1448858-61-4
Molecular Formula	C9H5F6NO
Molecular Weight	257.14 g/mol
Synonyms	2-(Trifluoroacetyl)-5-(trifluoromethyl)aniline; 3-Amino-4-(trifluoroacetyl)benzotrifluoride; 1-[2-Amino-4-(trifluoromethyl)phenyl]-2,2,2-trifluoroethanone; 2-Amino-α,α,α,α',α',α'-hexafluoro-4-methylacetophenone; 5-(Trifluoromethyl)-2-(trifluoroacetyl)aniline; 4-(Trifluoroacetyl)-3-aminobenzotrifluoride; α,α,α,α',α',α'-Hexafluoro-2-amino-4-methylacetophenone
EINECS	Contact for details

Quality Control

Our production of 1-[2-Amino-4-(Trifluoromethyl)Phenyl]-2,2,2-Trifluoroethan-1-One adheres to a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets precise customer specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. We support development and commercial projects requiring compliance with cGMP and other relevant regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under an inert atmosphere for prolonged procedures to ensure stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.