Description

tert-Butyl 3-Bromo-1H-pyrazolo[3,4-d]pyrimidine-1-carboxylate is a high-value, protected heterocyclic building block of significant interest in medicinal chemistry and advanced organic synthesis. This compound serves as a crucial synthetic intermediate for the development of kinase inhibitors and other biologically active molecules. It is primarily sought after by pharmaceutical R&D laboratories, agrochemical innovators, and fine chemical manufacturers engaged in the synthesis of complex nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potent and selective kinase inhibitors targeting various disease pathways.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Agrochemical Synthesis: Serves as a building block for novel active ingredients with herbicidal or fungicidal properties.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying cellular signaling pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for the custom synthesis of complex molecules under cGMP or research-grade conditions.
• Academic Research: Employed in university and institutional labs for methodological development and the synthesis of novel heterocyclic libraries.

Basic Information

Product Name	tert-Butyl 3-Bromo-1H-pyrazolo[3,4-d]pyrimidine-1-carboxylate
CAS No.	1448855-35-3
Molecular Formula	C10H11BrN4O2
Molecular Weight	299.13 g/mol
Synonyms	1-Boc-3-bromo-1H-pyrazolo[3,4-d]pyrimidine; 3-Bromo-1-(tert-butoxycarbonyl)-1H-pyrazolo[3,4-d]pyrimidine; tert-Butyl 3-bromo-1H-pyrazolo[3,4-d]pyrimidine-1-carboxylate; 1H-Pyrazolo[3,4-d]pyrimidine-1-carboxylic acid, 3-bromo-, 1,1-dimethylethyl ester; 3-Bromo-1-Boc-1H-pyrazolo[3,4-d]pyrimidine; Boc-3-Bromo-pyrazolopyrimidine; 1448855-35-3
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Bromo-1H-pyrazolo[3,4-d]pyrimidine-1-carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. Our quality system is designed to support customer needs from early-stage research through to pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Single Maximum Impurity	≤1.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.