Description

1-[6-(Trifluoromethyl)Pyrimidin-4-Yl]Piperidine-4-Carboxylic Acid is a high-value, multifunctional heterocyclic building block featuring a piperidine core fused with a trifluoromethyl-substituted pyrimidine ring. This compound is critical for medicinal chemistry research and development, offering a unique scaffold for modulating the physicochemical and pharmacokinetic properties of novel drug candidates. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of advanced intermediates for small molecule therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to introduce the trifluoromethyl group and piperidine-carboxylic acid moiety, which can enhance metabolic stability, membrane permeability, and target binding affinity.
• Agrochemical Synthesis: Acts as a precursor in the development of novel pesticides and herbicides, where the pyrimidine core and fluorine atoms contribute to biological activity and environmental stability.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands or organocatalysts for asymmetric synthesis, leveraging its nitrogen-rich heterocyclic structure.
• Chemical Biology Probes: Utilized to develop tool compounds and molecular probes for studying enzyme function and biological pathways in academic and industrial research settings.

Basic Information

Product Name	1-[6-(Trifluoromethyl)Pyrimidin-4-Yl]Piperidine-4-Carboxylic Acid
CAS No.	1448854-86-1
Molecular Formula	C11H12F3N3O2
Molecular Weight	275.23 g/mol
Synonyms	4-Piperidinecarboxylic acid, 1-[6-(trifluoromethyl)-4-pyrimidinyl]-; 1-(6-(Trifluoromethyl)pyrimidin-4-yl)piperidine-4-carboxylic acid; 4-(6-(Trifluoromethyl)pyrimidin-4-yl)piperidine-1-carboxylic acid (tautomer); 1-(6-(Trifluoromethyl)-4-pyrimidinyl)-4-piperidinecarboxylic acid; 1448854-86-1; 1-(6-(Trifluoromethyl)pyrimidin-4-yl)piperidine-4-carboxylate; 4-Piperidinecarboxylic acid, 1-[6-(trifluoromethyl)-4-pyrimidinyl]-, homopolymer
EINECS	Contact for details

Quality Control

Our 1-[6-(Trifluoromethyl)Pyrimidin-4-Yl]Piperidine-4-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing results from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.