Description

tert-Butyl 4-{[6-(Trifluoromethyl)Pyrimidin-4-Yl]Amino}Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine and trifluoromethylpyrimidine motifs. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of targeted small molecule therapeutics. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel drug candidates for oncology, CNS disorders, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and preclinical drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic targets.
• Kinase Inhibitor Development: Serves as a core scaffold or precursor for compounds targeting specific kinase enzymes, leveraging the pyrimidine moiety.
• Chemical Biology Probes: Employed in the development of molecular probes for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Library Synthesis: Used to generate focused chemical libraries for high-throughput screening (HTS) campaigns in drug discovery.

Basic Information

Product Name	tert-Butyl 4-{[6-(Trifluoromethyl)Pyrimidin-4-Yl]Amino}Piperidine-1-Carboxylate
CAS No.	1448854-71-4
Molecular Formula	C15H21F3N4O2
Molecular Weight	346.35 g/mol
Synonyms	1-Boc-4-[(6-(trifluoromethyl)pyrimidin-4-yl)amino]piperidine; tert-Butyl 4-((6-(trifluoromethyl)pyrimidin-4-yl)amino)piperidine-1-carboxylate; 4-((6-(Trifluoromethyl)pyrimidin-4-yl)amino)piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-[(6-(trifluoromethyl)-4-pyrimidinyl)amino]piperidine; BOC-4-((6-(Trifluoromethyl)pyrimidin-4-yl)amino)piperidine; 1448854-71-4
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-{[6-(Trifluoromethyl)Pyrimidin-4-Yl]Amino}Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.