Description

n-[(3R)-Pyrrolidin-3-Yl]Pyrimidin-4-Amine Dihydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant importance in modern drug discovery. This compound is valued for its role as a key synthon in the development of targeted small molecule therapeutics, particularly those acting on the central nervous system. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in neuroscience and oncology research.
• Kinase Inhibitor Development: Used in the research and production of selective kinase inhibitors due to its pyrimidine-amine scaffold.
• Chemical Biology Probes: Serves as a precursor for labeled compounds used in target identification and validation studies.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale manufacturing of APIs.
• Chiral Pool Synthesis: Provides a source of the (3R)-pyrrolidin-3-yl chiral center for asymmetric synthesis.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry programs and methodology development.

Basic Information

Product Name	n-[(3R)-Pyrrolidin-3-Yl]Pyrimidin-4-Amine Dihydrochloride
CAS No.	1448850-68-7
Molecular Formula	C8H13N5 · 2HCl
Molecular Weight	268.15 g/mol
Synonyms	4-Amino-N-[(3R)-3-pyrrolidinyl]pyrimidine dihydrochloride; (R)-N-(Pyrrolidin-3-yl)pyrimidin-4-amine dihydrochloride; (3R)-3-(Pyrimidin-4-ylamino)pyrrolidine dihydrochloride; 4-Pyrimidinamine, N-[(3R)-3-pyrrolidinyl]-, dihydrochloride; UNII-9F6L8J3V2F; Pyrrolidine, 3-[(4-pyrimidinyl)amino]-, (3R)-, dihydrochloride
EINECS	Contact for details

Quality Control

Our n-[(3R)-Pyrrolidin-3-Yl]Pyrimidin-4-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97%), and impurity profiles is provided with every shipment to guarantee reproducible results for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.