Description

tert-Butyl n-[(3S)-1-(Pyrimidin-4-Yl)Pyrrolidin-3-Yl]Carbamate is a high-purity chiral building block and pharmaceutical intermediate of significant importance in modern drug discovery. This compound is valued for its role in the synthesis of complex molecules targeting various therapeutic areas. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Organic Synthesis Building Block: Used in medicinal chemistry for constructing complex molecular architectures containing both pyrimidine and pyrrolidine motifs.
• Chemical Biology Research: Employed as a probe or precursor in the study of biological pathways and protein-ligand interactions.
• Process Chemistry Development: Serves as a critical intermediate during the scale-up and optimization of synthetic routes for potential APIs.
• Custom Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for client-specific projects requiring advanced heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl n-[(3S)-1-(Pyrimidin-4-Yl)Pyrrolidin-3-Yl]Carbamate
CAS No.	1448850-66-5
Molecular Formula	C17H24N4O2
Molecular Weight	316.40 g/mol
Synonyms	tert-Butyl (3S)-1-(pyrimidin-4-yl)pyrrolidin-3-ylcarbamate; (3S)-1-(Pyrimidin-4-yl)pyrrolidin-3-yl tert-butylcarbamate; tert-Butyl ((3S)-1-(pyrimidin-4-yl)pyrrolidin-3-yl)carbamate; Carbamic acid, N-[(3S)-1-(4-pyrimidinyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester; BOC-(S)-3-Amino-1-(4-pyrimidyl)pyrrolidine; (S)-tert-Butyl (1-(pyrimidin-4-yl)pyrrolidin-3-yl)carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl n-[(3S)-1-(Pyrimidin-4-Yl)Pyrrolidin-3-Yl]Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to minimize moisture absorption and ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.