Description

n-[(3S)-Pyrrolidin-3-Yl]Pyrimidin-2-Amine Dihydrochloride is a high-purity, chiral organic intermediate of significant importance in modern pharmaceutical research and development. This compound matters as a key building block for the synthesis of complex molecules, particularly those targeting central nervous system and other therapeutic areas. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and advanced chemical synthesis laboratories engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs).
• Drug Discovery Scaffold: Used as a core structural motif in medicinal chemistry for creating libraries of compounds targeting various receptors.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for candidate drugs during development phases.
• Biochemical Research: Utilized as a ligand or precursor in the study of biological pathways and enzyme inhibition.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	n-[(3S)-Pyrrolidin-3-Yl]Pyrimidin-2-Amine Dihydrochloride
CAS No.	1448850-62-1
Molecular Formula	C8H13N5 · 2HCl
Molecular Weight	268.14 g/mol (free base: 179.22 g/mol)
Synonyms	(S)-3-(2-Aminopyrimidin-4-yl)pyrrolidine dihydrochloride; 2-Pyrimidinamine, N-[(3S)-3-pyrrolidinyl]-, dihydrochloride; (S)-N-(Pyrrolidin-3-yl)pyrimidin-2-amine dihydrochloride; Pyrrolidine, 3-[(2-amino-4-pyrimidinyl)amino]-, (S)-, dihydrochloride; UNII-9XW9F3B2VK; 1448850-62-1; (S)-3-(2-Amino-pyrimidin-4-yl)-pyrrolidine dihydrochloride
EINECS	Contact for details

Quality Control

Our n-[(3S)-Pyrrolidin-3-Yl]Pyrimidin-2-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research and development grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.