Description

tert-Butyl (3S)-3-(Pyrimidin-4-Ylamino)Pyrrolidine-1-Carboxylate is a high-purity chiral building block and Boc-protected intermediate of significant value in modern synthetic chemistry. Its defined stereochemistry and functional groups make it a critical component for constructing complex molecular architectures with precision. This compound is primarily needed by pharmaceutical R&D and process chemistry teams for the development and scalable synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting kinase inhibition.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of targeted small-molecule drugs.
• Kinase Inhibitor Development: Serves as a core structural motif in the design and preparation of potent and selective kinase inhibitor candidates.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and cGMP manufacturing for advanced pharmaceutical intermediates.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and library synthesis for lead optimization.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke chemical synthesis projects.
• Academic & Institutional Research: Utilized in chemical biology and methodological development studies within university and institutional labs.

Basic Information

Product Name	tert-Butyl (3S)-3-(Pyrimidin-4-Ylamino)Pyrrolidine-1-Carboxylate
CAS No.	1448850-56-3
Molecular Formula	C13H20N4O2
Molecular Weight	264.33 g/mol
Synonyms	1-Boc-3-((pyrimidin-4-yl)amino)-(S)-pyrrolidine; (3S)-1-(tert-Butoxycarbonyl)-3-(pyrimidin-4-ylamino)pyrrolidine; tert-Butyl (3S)-3-[(pyrimidin-4-yl)amino]pyrrolidine-1-carboxylate; (S)-tert-Butyl 3-(pyrimidin-4-ylamino)pyrrolidine-1-carboxylate; 1-N-Boc-3-N-(pyrimidin-4-yl)-(S)-pyrrolidine-1,3-diamine; Boc-L-3-(4-Pyrimidylamino)proline tert-butyl ester (related); 1448850-56-3
EINECS	Contact for details

Quality Control

Our tert-Butyl (3S)-3-(Pyrimidin-4-Ylamino)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure compliance with exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), and specific impurity limits is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.