Description

n-[(3R)-Pyrrolidin-3-Yl]-6-(Trifluoromethyl)Pyrimidin-4-Amine Dihydrochloride is a high-purity, chiral organic compound with a defined stereochemistry, serving as a critical building block in advanced pharmaceutical research and development. Its value lies in its role as a sophisticated intermediate for synthesizing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting the central nervous system and oncology. This compound is essential for medicinal chemists and process development scientists in pharmaceutical companies and contract research organizations (CROs) who require reliable, high-quality chemical intermediates to accelerate drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for neurological and oncological targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its defined 3R stereochemistry and pyrimidine core.
• Process Chemistry & Scale-up: Serves as a starting material or intermediate in the development of scalable synthetic routes for potential Active Pharmaceutical Ingredients (APIs).
• Biochemical Tool Compound: May be utilized in biochemical assays and as a probe for investigating specific biological pathways and enzyme interactions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and pre-clinical sample production.

Basic Information

Product Name	n-[(3R)-Pyrrolidin-3-Yl]-6-(Trifluoromethyl)Pyrimidin-4-Amine Dihydrochloride
CAS No.	1448850-53-0
Molecular Formula	C9H12Cl2F3N5
Molecular Weight	318.13 g/mol
Synonyms	(3R)-3-[[6-(Trifluoromethyl)pyrimidin-4-yl]amino]pyrrolidine dihydrochloride; 6-(Trifluoromethyl)-N-[(3R)-3-pyrrolidinyl]-4-pyrimidinamine dihydrochloride; (R)-3-((6-(Trifluoromethyl)pyrimidin-4-yl)amino)pyrrolidine dihydrochloride; 4-Pyrimidinamine, N-[(3R)-3-pyrrolidinyl]-6-(trifluoromethyl)-, hydrochloride (1:2); CAS 1448850-53-0
EINECS	Contact for details

Quality Control

Our n-[(3R)-Pyrrolidin-3-Yl]-6-(Trifluoromethyl)Pyrimidin-4-Amine Dihydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as chiral purity, chemical purity, and impurity profiles. Our quality commitment aligns with the standards expected in pharmaceutical development, ensuring reliable material for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.