Description

2-(4-Fluoro-1H-Pyrazol-1-Yl)Pyrimidine-5-Carboxylic Acid is a high-purity, heterocyclic carboxylic acid derivative that serves as a critical building block in modern organic synthesis. This compound is valued for its unique pyrazole-pyrimidine scaffold, which is essential for constructing molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, particularly in kinase inhibitor programs.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and fungicides, leveraging its fluorinated heterocyclic structure.
• Chemical Research: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Ligand & Catalyst Development: Employed in the design of novel ligands for metal catalysis and organocatalysts due to its nitrogen-rich, chelating architecture.
• Material Science: Investigated as a monomer or functional additive for creating specialty polymers with specific electronic or thermal properties.

Basic Information

Product Name	2-(4-Fluoro-1H-Pyrazol-1-Yl)Pyrimidine-5-Carboxylic Acid
CAS No.	1447607-77-3
Molecular Formula	C8H5FN4O2
Molecular Weight	208.15 g/mol
Synonyms	2-(4-Fluoropyrazol-1-yl)pyrimidine-5-carboxylic acid; 5-Pyrimidinecarboxylic acid, 2-(4-fluoro-1H-pyrazol-1-yl)-; 1447607-77-3; 2-(4-Fluoro-1H-pyrazol-1-yl)pyrimidine-5-carboxylic acid; 2-(4-Fluoro-pyrazol-1-yl)-pyrimidine-5-carboxylic acid; 2-(4-Fluoropyrazol-1-yl)pyrimidine-5-carboxylic acid; 2-(4-Fluoro-1H-pyrazol-1-yl)-5-pyrimidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our production of 2-(4-Fluoro-1H-Pyrazol-1-Yl)Pyrimidine-5-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Every lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, NMR for structural confirmation, and KF titration for moisture content. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.