Description

8-Bromo-2-Phenylimidazo[1,2-C]Pyrimidin-5(6H)-One is a high-value heterocyclic building block and advanced pharmaceutical intermediate. This compound is critical for medicinal chemistry research and the development of novel therapeutic agents, particularly in kinase inhibitor programs. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: Serves as a key scaffold in the synthesis of targeted small molecule drugs, especially protein kinase inhibitors.
• Medicinal Chemistry Research: Used extensively in hit-to-lead optimization and structure-activity relationship (SAR) studies for new chemical entities.
• Chemical Biology Probes: Employed in the development of tool compounds for studying cellular signaling pathways and target validation.
• Organic Synthesis Building Block: Provides a versatile brominated imidazopyrimidine core for further functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig).
• Agrochemical Research: Potential intermediate in the discovery of new active ingredients for crop protection.

Basic Information

Product Name	8-Bromo-2-Phenylimidazo[1,2-C]Pyrimidin-5(6H)-One
CAS No.	1447607-49-9
Molecular Formula	C12H8BrN3O
Molecular Weight	290.12 g/mol
Synonyms	8-Bromo-2-phenyl-5,6-dihydroimidazo[1,2-c]pyrimidin-5-one; 8-Bromo-2-phenylimidazo[1,2-c]pyrimidin-5(6H)-one; 1447607-49-9; Imidazo[1,2-c]pyrimidin-5(6H)-one, 8-bromo-2-phenyl-; 2-Phenyl-8-bromoimidazo[1,2-c]pyrimidin-5(6H)-one
EINECS	Contact for details

Quality Control

Our 8-Bromo-2-Phenylimidazo[1,2-C]Pyrimidin-5(6H)-One is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.