Description

n-(2-Chloro-5-Methoxypyrimidin-4-Yl)-1H-Indazol-6-Amine CAS NO 1447607-39-7 is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyrimidine-indazole hybrid structure. This compound is of critical importance for research and development in medicinal chemistry, serving as a key building block for the synthesis of novel therapeutic agents. It is primarily sought after by pharmaceutical companies, biotechnology research firms, and academic institutions engaged in drug discovery programs targeting kinase inhibition and other high-value biological pathways.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of targeted small-molecule drugs, particularly kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to develop new chemical entities with improved efficacy and selectivity.
• Biochemical Probe Development: Serves as a core scaffold for creating tool compounds to study specific enzyme functions and cellular signaling pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and development projects for global clients.
• Oncology & Immunology Drug Discovery: Applied in the research of potential treatments for cancers and autoimmune diseases due to its relevance in modulating key biological targets.
• Process Chemistry & Scale-Up: Used in the development and optimization of robust, scalable synthetic routes for potential Active Pharmaceutical Ingredients (APIs).

Basic Information

Item	Details
Product Name	n-(2-Chloro-5-Methoxypyrimidin-4-Yl)-1H-Indazol-6-Amine
CAS No.	1447607-39-7
Molecular Formula	C13H11ClN6O
Molecular Weight	302.72 g/mol
Synonyms	6-((2-Chloro-5-methoxypyrimidin-4-yl)amino)-1H-indazole; 1H-Indazol-6-amine, N-(2-chloro-5-methoxypyrimidin-4-yl)-; 1447607-39-7; 4-(1H-Indazol-6-ylamino)-2-chloro-5-methoxypyrimidine; N-(2-Chloro-5-methoxypyrimidin-4-yl)-1H-indazol-6-amine; 2-Chloro-5-methoxy-N-(1H-indazol-6-yl)pyrimidin-4-amine
EINECS	Contact for details

Quality Control

Our n-(2-Chloro-5-Methoxypyrimidin-4-Yl)-1H-Indazol-6-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring consistency and reliability for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.